A Correlational Study on CALLY Index as a Potential Predictive Indicator for Postoperative in-Hospital Mortality in...

Area of Science:

• Cardiovascular Surgery
• Biomarkers
• Medical Informatics

Background:

• Acute Type A Aortic Dissection (ATAAD) presents a high risk of postoperative in-hospital mortality (POIM).
• Effective preoperative risk stratification is crucial for managing ATAAD patients.
• Existing assessment tools may not fully capture the complexity of POIM risk in ATAAD.

Purpose of the Study:

• To evaluate the predictive capability of the preoperative CRP-albumin-lymphocyte (CALLY) index for POIM in ATAAD patients.
• To develop and validate a nomogram model incorporating the CALLY index for enhanced POIM prediction.

Main Methods:

• Retrospective analysis of 522 surgically treated ATAAD patients.
• Logistic regression and LASSO regression for predictor identification and model development.
• Internal and external validation of the nomogram model.

Main Results:

• The CALLY index is an independent protective factor for POIM (OR=0.131) with superior predictive performance (AUC=0.820) compared to individual components.
• Lower CALLY index was associated with increased rates of postoperative complications.
• The nomogram integrating CALLY index and other clinical variables demonstrated strong predictive accuracy (AUC=0.843-0.869).

Conclusions:

• The preoperative CALLY index is a valuable predictor of POIM in ATAAD.
• The developed nomogram offers a practical tool for perioperative decision-making and risk stratification in ATAAD.
• The CALLY index shows consistent predictive value across various patient subgroups.