Enhanced Electrochemical Sensing of Treprostinil: A Novel Approach for Sensitive and Selective Detection

Treprostinil (TRP) is a potent vasodilator used in the treatment of pulmonary arterial hypertension (PAH). The development of a rapid, sensitive, and selective electrochemical detection method for TRP is crucial for therapeutic monitoring and quality control. In this study, we present a novel electrochemical sensor for TRP based on NiPB@Cu/Cu₂O/GCE. The NiPB@Cu/Cu₂O/GCE sensor exhibits excellent sensitivity and selectivity, enabling reliable quantification of TRP in biological and pharmaceutical samples. The nanomaterial used in the sensor was characterized using field emission scanning electron microscopy (FE-SEM), scanning transmission electron microscopy (STEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR) to confirm its structural and morphological properties. The developed sensor demonstrated a wide linear range, low detection limit, and high reproducibility, making it a promising tool for clinical and pharmaceutical applications. This study provides a significant advancement in the electrochemical analysis of TRP, paving the way for further applications in drug monitoring and biomedical research.