Near-Infrared Light-Responsive Copper Selenide Nanoparticle-Loaded Calcium Silicate Cement Induces Immunogenic Cell...

Area of Science:

• Biomaterials Science
• Oncology
• Nanotechnology

Background:

• Osteosarcoma presents significant treatment challenges, including poor bone defect repair and limited conventional therapy efficacy.
• Calcium silicate cement (CS) is a viable bone filler but lacks antitumor properties, hindering its oncological application.

Purpose of the Study:

• To develop a multifunctional composite bone cement for osteosarcoma treatment.
• To evaluate the material's photothermal, mechanical, and antitumor properties.
• To investigate the induction of immunogenic cell death (ICD) in tumor cells.

Main Methods:

• Incorporation of nano-Cu2-xSe photothermal agent into a CS matrix.
• Assessment of photothermal performance, setting time, and compressive strength.
• In vitro and in vivo evaluation of antitumor efficacy and ICD induction.

Main Results:

• The composite cement demonstrated effective photothermal conversion under NIR irradiation for photothermal therapy (PTT).
• Improved mechanical properties, including shorter setting time and higher compressive strength, were observed compared to pure CS.
• Significant in vitro and in vivo antitumor efficacy was confirmed, with evidence of ICD induction in tumor cells.

Conclusions:

• The developed composite cement offers a dual-functional system for bone defect repair and photothermal antitumor therapy.
• The material exhibits promising potential for treating bone tumors, with possible immunogenic effects.
• This preclinical strategy warrants further development for bone tissue engineering and oncology applications.