Related Experiment Video
Updated: May 3, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Dentin Hypersensitivity Treated With Diode Laser and Aminefluoride: A Randomized Clinical Trial
Domenico Aiello1, Mario Romeo2, Melania Reda3
1Department of Health, University "Magna Graecia" of Catanzaro, Viale Europa, Loc. Germaneto, Catanzaro 88100, Italy.
Objectives:
The aim of this trial was to evaluate the effect of amine fluoride (AF) gel with or without diode laser application on pain due to dentin hypersensitivity (DH).
Methods:
The numerical rating scale (NRS) index was used to assess the pain experienced by each patient. The pain response was elicited by a thermal stimulus (cold air blast). The sample included 43 patients, for a total of 86 dental elements with a split-mouth design, 27 females and 16 males, with an age range between 18 and 68 years. The teeth were divided into two groups. The treatment group, consisting of 43 teeth, was treated with 980 nm diode laser (doctor smile wiser by Lambda s.p.a. Via dell'Impresa, 1,36040 Brendola VI, Italy) and AF gel (Elmex Dental Gel, Colgate-Palmolive company, New York, 300 Park Ave, United States); the control group, consisting of 43 teeth, was treated with AF gel only. Only one treatment session was performed for each group. Follow-up visits were scheduled for each patient at 1 week, 1, 3, and 6 months. At these follow-up sessions, the pain response was reassessed using the NRS index.
Results:
The results of this study showed a significant reduction in pain in both groups (p < 0.05). However, teeth treated with laser therapy showed significantly better pain control over time compared with conventional treatment (p > 0.05). AF therapy combined with laser therapy was shown to be more effective in reducing pain than AF alone, both immediately after therapy and in the long term (p < 0.05).
Conclusions:
The laser combined with the AF gel guarantees a better result on reduction of tooth sensitivity compared to the AF gel alone.

