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Dentin Hypersensitivity Treated With Diode Laser and Aminefluoride: A Randomized Clinical Trial.
Domenico Aiello1, Mario Romeo2, Melania Reda3
1Department of Health, University "Magna Graecia" of Catanzaro, Viale Europa, Loc. Germaneto, Catanzaro 88100, Italy.
International Journal of Dentistry
|November 17, 2025
Summary
Diode laser combined with amine fluoride (AF) gel significantly reduces dentin hypersensitivity (DH) pain. This combination therapy offers superior long-term pain relief compared to AF gel alone for treating DH.
Area of Science:
- Dentistry
- Biomedical Engineering
- Pain Management
Background:
- Dentin hypersensitivity (DH) is a common dental condition causing significant pain.
- Current treatments for DH include topical agents like amine fluoride (AF) gel.
- Novel therapeutic approaches are needed to enhance pain relief for DH.
Purpose of the Study:
- To evaluate the efficacy of amine fluoride (AF) gel with diode laser therapy versus AF gel alone in managing dentin hypersensitivity (DH).
- To compare the pain reduction outcomes between the two treatment groups over a 6-month period.
Main Methods:
- A split-mouth study design involving 43 patients (86 teeth) was employed.
- Teeth were treated with either 980 nm diode laser plus AF gel or AF gel alone.
- Pain was assessed using the Numerical Rating Scale (NRS) following thermal stimuli at baseline and at 1 week, 1, 3, and 6 months post-treatment.
Main Results:
- Both treatment groups showed a significant reduction in DH pain (p < 0.05).
- The diode laser combined with AF gel demonstrated significantly superior pain control over time compared to AF gel alone (p > 0.05).
- The combined therapy was more effective immediately after treatment and in the long term (p < 0.05).
Conclusions:
- Diode laser therapy in conjunction with AF gel provides enhanced pain reduction for dentin hypersensitivity.
- The combination therapy is a more effective treatment option for DH than AF gel alone.
- This approach offers significant benefits for long-term management of tooth sensitivity.

