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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Preparation and Photoacoustic Analysis of Cellular Vehicles Containing Gold Nanorods
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Nucleus-Targeted Delivery of Anticancer Drug Using Alpha-Synuclein(Y136C)-Gold Nanoparticle Conjugates.

Jeongha Park1, Seung R Paik1,2

  • 1School of Chemical and Biological Engineering, Institute of Engineering Research, College of Engineering, Seoul National University, Seoul 08826, Republic of Korea.

ACS Materials Au
|November 17, 2025
PubMed
Summary

This study introduces a novel nanoparticle system using gold nanoparticles conjugated with alpha-synuclein to deliver doxorubicin directly to the cell nucleus for enhanced cancer therapy.

Keywords:
gold nanoparticleheat-sensitive cross-linkernuclear-targeted anticancer drugphotothermal effectα-synuclein

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Cancer Research

Background:

  • The cell nucleus is crucial for eukaryotic cell survival and a key target in cancer therapy.
  • Conventional nucleus-directed anticancer drugs like doxorubicin (Dox) exhibit limitations in cellular uptake and nuclear delivery.
  • Nanoparticle-based systems offer potential solutions for overcoming these drug delivery challenges.

Purpose of the Study:

  • To develop an intracellular drug delivery system for nucleus-targeted cancer therapy.
  • To utilize alpha-synuclein-gold nanoparticle conjugates (αS-AuNPs) for enhanced drug delivery and nuclear accumulation.
  • To achieve controlled drug release using near-infrared (NIR) irradiation and photothermal effects.

Main Methods:

  • Conjugation of α-synuclein (αS) with gold nanoparticles (AuNPs) to form αS-AuNPs.
  • Linking doxorubicin (Dox) to αS-AuNPs via a heat-labile cross-linker.
  • Utilizing NIR irradiation to trigger photothermal effect and induce localized hyperthermia for drug release.
  • Evaluating the efficacy of the Dox-αS-AuNP system for nucleus-targeted cancer therapy.

Main Results:

  • αS-AuNPs demonstrated efficient cellular uptake and nuclear accumulation.
  • NIR irradiation successfully triggered the cleavage of the heat-labile linker, releasing Dox.
  • Localized hyperthermia induced by AuNPs facilitated controlled Dox release within the nucleus.
  • Enhanced anticancer efficacy was observed with the nucleus-targeted Dox-αS-AuNP system.

Conclusions:

  • Dox-αS-AuNP is a promising nucleus-targeted drug delivery system for cancer therapy.
  • The system enables controlled and efficient delivery of doxorubicin to the cell nucleus.
  • This approach holds potential for improving cancer treatment outcomes by enhancing drug efficacy.