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Monitoring Endoplasmic Reticulum Calcium Homeostasis Using a Gaussia Luciferase SERCaMP
Published on: September 6, 2015
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A new probe illuminates endo-lysosomal Ca2+ measurements: A role for vesicular IP3 receptors?
1Department of Pharmacology, University of Oxford, Oxford, UK.
The Journal of Cell Biology
|November 17, 2025
Abstract:
In this issue, Calvo et al. (https://doi.org/10.1083/jcb.202410094) report a new bioluminescent Ca2+ probe (ELGA) targeted to acidic endo-lysosomes (ELs) to permit selective and dynamic recording of endo-lysosomal Ca2+ uptake and release. Ca2+ was not only released by canonical EL channels but, surprisingly, by IP3 receptors.

