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The Efficacy of Ibuprofen for Postoperative Pain Following Laparoscopic Cholecystectomy: A Randomised Controlled
Azime Bulut1, Fatma Alkan Bayburt1, Ilke Tamdogan1
1Department of Anaesthesiology and Reanimation, Faculty of Medicine, Giresun University Training and Research Hospital, Giresun, Turkiye.
Objective:
To compare the effects of intravenous (IV) ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
Study Design:
Randomised-controlled study. Place and Duration of the Study: Department of Anaesthesiology and Reanimation, Giresun University Training and Research Hospital, Giresun, Turkiye, from February to April 2024.
Methodology:
The patients undergoing laparoscopic cholecystectomy were randomised into two groups: Group I (n = 35; administered 800 mg of ibuprofen) and Group A (n = 36; administered 1000 mg of acetaminophen). Demographic data, including gender, age, American Society of Anaesthesiologists (ASA) classification, body mass index (BMI), duration of anaesthesia and surgery, incidence of postoperative nausea and vomiting (PONV), length of hospital stay (LOS), visual analogue scale (VAS) scores, and opioid consumption, were recorded. To compare the two independent groups, the Student's t-test was used for parametric data, whereas the Mann-Whitney U-test was employed for non-parametric variables. A p-value <0.05 was considered statistically significant.
Results:
Demographic data such as age, gender, BMI, and ASA scores were similar in both groups. The pain scores at recovery, 12, and 24 hours were lower in Group I (p <0.05). However, the VAS scores were similar at 2 and 6 (p >0.05). While the peak VAS scores were similar between the groups, the VAS scores at discharge were found to be significantly lower in Group I (p= 0.271, 0.001 respectively). In terms of total tramadol consumption, 24-hour consumption was lower in Group I (100 [0-300] and 0 [0-300] mg, respectively; p = 0.001).
Conclusion:
The present study suggests that the IV administration of ibuprofen results in lower pain scores and reduced opioid consumption compared with the administration of acetaminophen postoperatively in patients undergoing laparoscopic cholecystectomy.
Key Words:
Intravenous ibuprofen, Acetaminophen, Laparoscopic cholecystectomy, Postoperative pain control, Analgesia, Anti-inflammatory agents.
