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Enhanced nursing and ganciclovir improve outcomes in paediatric Epstein-Barr Virus infectious mononucleosis: A
Yu Sun1, Wang YanHua1, Shuai Liang2
1Department of Paediatrics, Tangshan Maternal and Child Health Hospital's Five, Tangshan, China.
Insights
High-quality nursing care and ganciclovir significantly improved treatment outcomes for pediatric Epstein-Barr virus infectious mononucleosis. This combination therapy enhanced symptom reduction and laboratory markers in young patients.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Nursing Research
Background:
- Epstein-Barr virus infectious mononucleosis (EBV-IM) is common in children.
- Effective treatment strategies for pediatric EBV-IM require further investigation.
Purpose of the Study:
- To evaluate the efficacy of high-quality nursing interventions combined with ganciclovir for pediatric EBV-IM.
- To compare outcomes between the intervention group and a control group receiving standard care.
Main Methods:
- A randomized controlled trial involving 100 pediatric patients diagnosed with EBV-IM.
- Intervention group received nursing care plus ganciclovir; control group received standard care.
- Primary outcomes: symptom reduction, laboratory markers. Secondary outcomes: hospital stay, symptom resolution time, adverse events, patient-reported outcomes.
Main Results:
- The intervention group (n=50) showed statistically significant improvements compared to the control group (n=50) (p<0.05).
- Specific improvements noted in symptom reduction and key laboratory markers.
- No significant differences in adverse events were detailed in the abstract.
Conclusions:
- Ganciclovir combined with high-quality nursing interventions is an effective treatment for pediatric EBV-IM.
- This combined approach offers a superior treatment option compared to standard care.
- Further research could explore long-term effects and patient-reported quality of life.
Objective:
To investigate the impact of high-quality nursing interventions and ganciclovir on paediatric Epstein-Barr virus infectious mononucleosis.
Methods:
The randomised controlled trial was conducted from March to August 2021 at the Departments of Paediatrics, Maternal and Child Health Hospital, Tangshan, China, and comprised paediatric patients diagnosed with Epstein-Barr virus infectious mononucleosis. The patients were randomised into intervention group A receiving high-quality nursing interventions and ganciclovir, and control group B receiving routine standard care. Primary outcomes included symptom reduction and laboratory markers, while secondary outcomes included length of hospital stay, time to resolution of symptoms, adverse events, and patient-reported outcomes. Data was analysed using SPSS 28.
Results:
Of the 100 subjects, 50(50%) were in group A; 31(62%) boys and 19(38%) girls with mean age 9.15±1.45 years. There were 50(50%) patients in group B; 30(60%) boys and 20(40%) girls with mean age 9.15±1.34 years. Group A demonstrated improvements in outcomes compared to group B (p<0.05).
Conclusions:
Ganciclovir and good nursing improved paediatric Epstein-Barr virus infectious mononucleosis treatment.
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