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Kidney diseases and the thyroid: interactions and consequences
1Endocrinology and Metabolism Division, Unidad Asistencial Dr. César Milstein, Buenos Aires, Argentina. gbrenta@gmail.com.
Nature Reviews. Endocrinology
|November 17, 2025
Summary
Thyroid dysfunction, particularly hypothyroidism, may contribute to chronic kidney disease (CKD) progression. Further research is needed to confirm if treating hypothyroidism can improve kidney function in CKD patients.
Area of Science:
- Nephrology
- Endocrinology
- Internal Medicine
Background:
- Reduced survival rates in renal impairment necessitate identifying comorbidities.
- Thyroid dysfunction is a potential determinant of chronic kidney disease (CKD).
- Thyroid hormones are crucial for kidney structure and function.
Purpose of the Study:
- To explore the role of thyroid dysfunction, specifically hypothyroidism, in renal function deterioration.
- To investigate hypothyroidism as a potentially reversible risk factor for CKD.
Main Methods:
- This is a narrative review.
- Analysis of existing studies on thyroid function and kidney disease.
Main Results:
- Subclinical hypothyroidism is more prevalent in CKD patients.
- Hypothyroidism may be a risk factor for CKD development.
- The causal role of hypothyroidism in CKD and the efficacy of levothyroxine treatment remain unclear.
Conclusions:
- Thyroid dysfunction warrants consideration as a reversible factor in CKD progression.
- Further investigation is required to establish causality and treatment benefits.
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