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Related Concept Videos

Brain Imaging01:14

Brain Imaging

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Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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A Human Cerebral Organoid Model of Neural Cell Transplantation
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"Time Is Brain" - for Cell Therapies.

Hao Yin1, Dominikus Brian2, Rebecca Z Weber3,4

  • 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, London, Ontario, N6A 5C1, Canada.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 18, 2025
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Summary
This summary is machine-generated.

Timing is crucial for stem cell therapy after stroke. Optimal delivery depends on the evolving brain environment and cell type, not just the acute window, to maximize therapeutic benefits.

Keywords:
cell therapycell transplantationneural stem cellsstroke

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stroke Research

Background:

  • The
  • time is brain
  • principle guides acute stroke care, prioritizing rapid intervention.
  • Its application to stem cell therapy, a regenerative approach, is under investigation.

Purpose of the Study:

  • To evaluate the significance of cell delivery timing in stem cell therapy for stroke.
  • To explore how the post-stroke microenvironment influences graft survival and efficacy.
  • To determine if the optimal timing for stem cell transplantation varies by cell type and mechanism.

Main Methods:

  • Review of preclinical and clinical studies on stem cell transplantation timing in stroke models.
  • Analysis of the evolving post-stroke microenvironment (inflammation, tissue status).
  • Correlation of cell delivery windows with graft survival, integration, and therapeutic outcomes.

Main Results:

  • Early transplantation accesses salvageable tissue but faces inflammation.
  • Later transplantation occurs in a permissive environment but with greater tissue loss.
  • Optimal timing is cell-type and mechanism-dependent (e.g., neuroprotection vs. long-term integration).

Conclusions:

  • The
  • time is brain
  • concept applies to stem cell therapy, but requires aligning delivery with the dynamic post-stroke microenvironment.
  • Personalized timing strategies, guided by biomarkers, are needed for future clinical trials.