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Updated: Jun 30, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
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Published on: July 8, 2025

Pregabalin-Induced Myoclonus in a Patient Without Kidney Dysfunction.

Sokena Zaidi1, Patrick D Lyden1,2

  • 1Department of Neurology, Keck School of Medicine, 1540 Alcazar Street Suite 215, Los Angeles, 90033, California, USA, usc.edu.

Case Reports in Neurological Medicine
|June 29, 2026
PubMed
Summary
This summary is machine-generated.

Pregabalin, commonly used for nerve pain and seizures, can cause rare but serious positive myoclonus. This case report highlights a patient experiencing transient neurological deficits and jerking movements, emphasizing the need for awareness of this adverse effect.

Keywords:
nephrotoxicitypositive myoclonuspregabalin

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Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Pregabalin is widely prescribed for neuropathic pain and seizures.
  • Common adverse effects include dizziness and somnolence.
  • Renal function influences pregabalin dosing.

Purpose of the Study:

  • To report a rare case of positive myoclonus associated with pregabalin use.
  • To describe transient neurological deficits preceding myoclonus in a patient without renal dysfunction.

Main Methods:

  • Case report presentation.
  • Review of patient's medical history and medication.
  • Clinical observation of neurological deficits and myoclonus.

Main Results:

  • A patient on long-term pregabalin without renal impairment presented with stroke-like transient neurological deficits.
  • These deficits were followed by jerking movements consistent with positive myoclonus.
  • This presentation is rare, especially compared to negative myoclonus.

Conclusions:

  • Pregabalin can cause positive myoclonus, a rare but serious adverse effect.
  • Transient neurological deficits may precede myoclonus in pregabalin users.
  • Clinicians should consider pregabalin-induced myoclonus in patients presenting with these symptoms.