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Redox-Responsive Tellurium-Bridged Covalent Organic Frameworks/PEG Composites for Targeted Therapy of Diabetic

Jing Xue1, Jialu Zhuang2, Taotao Fan3

  • 1Department of Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, 230032, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|November 18, 2025
PubMed

Insights

A novel tellurium-bridged covalent organic framework (Te-COF) nanocomposite effectively lowers glycated hemoglobin (HbA1c) and reactive oxygen species (ROS) in diabetic models. This breakthrough offers a promising therapeutic strategy for diabetic cardiomyopathy.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Diabetic cardiomyopathy is linked to high HbA1c and ROS levels.
  • Current treatments struggle to address both HbA1c and ROS simultaneously.
  • Novel therapeutic agents are needed for effective diabetic cardiomyopathy management.

Purpose of the Study:

  • To develop a multifunctional platform for simultaneous HbA1c and ROS reduction.
  • To investigate the therapeutic potential of redox-responsive Te-COF@PEG nanocomposites.
  • To evaluate the efficacy of Te-COF@PEG2000 in preclinical models of diabetic cardiomyopathy.

Main Methods:

  • Synthesis of redox-responsive tellurium-bridged covalent organic frameworks (Te-COF) functionalized with polyethylene glycol (PEG).
  • In vitro evaluation of Te-COF@PEG composites for HbA1c and glycated protein removal from diabetic patient plasma.
  • In vivo assessment of Te-COF@PEG2000 efficacy in diabetic mouse and rabbit models, including analysis of blood glucose, HbA1c, inflammatory markers, and cardiac function.

Main Results:

  • Te-COF@PEG composites efficiently removed HbA1c and glycated proteins, lowering blood glucose without affecting other serum components.
  • Te-COF@PEG2000 significantly reduced fasting blood glucose, HbA1c, and inflammatory factors in diabetic animal models.
  • Te-COF@PEG2000 promoted M2 macrophage polarization, inhibited cardiomyocyte apoptosis, scavenged ROS, and ameliorated myocardial injury.

Conclusions:

  • COF@polymer nanocomposites represent a promising multifunctional platform for diabetic cardiomyopathy therapy.
  • Te-COF@PEG2000 demonstrates significant therapeutic potential by simultaneously targeting key pathological pathways.
  • This approach offers a novel strategy for managing diabetic complications affecting the heart.

Keywords:
covalent organic frameworksdiabetic cardiomyopathyglycated hemoglobinreactive oxygen species

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