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Updated: Jan 11, 2026
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Published on: January 10, 2017
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Chiral Luminescent Sensor for Enantiomer Discrimination
Vivek Sharma1, Akash Kumar Mishra2, Neeraj Kumar Mishra2
1Department of Chemistry, GLA University, Mathura, India.
Chirality
|November 18, 2025
Summary
Chiral fluorescent sensors using nanomaterials like quantum dots and MOFs offer precise enantiomer detection for drugs and biomolecules. Advances focus on hybrid structures for improved sensitivity and real-world applications.
Area of Science:
- Nanomaterials Science
- Analytical Chemistry
- Pharmaceutical Sciences
Background:
- Chiral recognition is crucial for drug safety and efficacy, necessitating selective enantiomer detection.
- Recent advancements have focused on developing chiral fluorescent sensors with enhanced sensitivity, selectivity, and biocompatibility.
Purpose of the Study:
- To review the structural design, functionalization, and sensing mechanisms of advanced chiral fluorescent sensors.
- To highlight the integration of hybrid nanostructures and multifunctional composites for next-generation enantioselective sensing platforms.
Main Methods:
- Review of recent literature on carbon-based quantum dots (CQDs, CCDs, GQDs), MOFs, and composite nanomaterials for chiral sensing.
- Analysis of specific examples, including functionalized GQDs, modified QDs, and MOF-based composites.
- Discussion of sensing mechanisms involving fluorescence, electrochemiluminescence, and coordination chemistry.
Main Results:
- Development of graphene quantum dots functionalized with D-cysteine for morphine enantiomer discrimination.
- CdSe/ZnS QDs modified with L-pyroglutamic acid derivatives for stereoselective amino acid detection.
- Zn-MOC@CQDs and Eu-BTB@D-carnitine MOFs demonstrate enantioselective sensing for lactic acid and enhanced fluorescence recognition.
- BINOL-derived and carbazole-based sensors achieve high enantioselectivity and ultralow detection limits for amino acids.
Conclusions:
- Rational design of chiral nanomaterials, particularly hybrid and composite structures, is key to precise enantiomer discrimination.
- These advanced sensors show significant potential for applications in drug analysis, biosensing, and food quality monitoring.
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