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The UCSC Genome Browser database: 2026 update
Jonathan Casper1, Matthew L Speir1, Brian J Raney1
1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, United States.
Nucleic Acids Research
|November 18, 2025
Summary
The UCSC Genome Browser offers updated tools for comparing genome annotations. New features include a heatmap for mutation data, QuickLift for assembly data transfer, and HubSpace for simplified track hub creation.
Area of Science:
- Genomics
- Bioinformatics
- Computational Biology
Background:
- The UCSC Genome Browser has been a key resource for 25 years.
- Researchers require tools to visualize and compare genomic annotations across different assemblies.
Purpose of the Study:
- To introduce significant updates to the UCSC Genome Browser.
- To enhance data visualization, data transfer, and track hub management for researchers.
Main Methods:
- Implemented a positional heatmap display for mutation consequence data from MaveDB.
- Developed QuickLift for copying annotation data between genome assemblies.
- Introduced HubSpace to streamline track hub creation and usage with dedicated storage.
Main Results:
- A new heatmap visualization is available for functional mutation data.
- QuickLift enables efficient annotation data transfer across related assemblies.
- HubSpace simplifies track hub management, offering dedicated user storage.
Conclusions:
- The updated UCSC Genome Browser provides enhanced capabilities for genomic data analysis and sharing.
- New features improve the visualization of mutation consequences and the management of genomic annotations.
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