Related Experiment Video
Updated: Jan 11, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Catalyst-Free [3 + 2] Cycloaddition of Benzimidazole Esters and Quinone Esters: Divergent Synthesis of N-Heterocycles
Si-Chao Wu1,2, Shi-Jie Liu2, Fu-Cai Rao2
1School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies, Taizhou University, Taizhou 318000, Zhejiang, China.
Abstract:
Herein, we disclose a catalyst-free [3 + 2] cycloaddition of benzimidazole esters and quinone esters for the efficient and atom-economical construction of benzo[d]imidazol-2-ylidene-2,3-dihydrobenzofurans in good to excellent yield with excellent E-type selectivity. Interestingly, subsequent lactamization leads to divergent synthesis of valuable benzo[4,5]imidazo[1,2-b]furo[4,3,2-de]isoquinoline derivatives with high efficiency without column chromatography isolation under base conditions. In addition, this cycloaddition also features theoretical calculations, mild conditions, broad substrate scope, and great potential for optical activity.
More Related Videos
10:17Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
07:36Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
Published on: November 9, 2019
Related Concept Videos
Cycloaddition Reactions: Overview
[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction
Cycloaddition Reactions: MO Requirements for Thermal Activation
Reduction of Benzene to Cyclohexane: Catalytic Hydrogenation
Nucleophilic Aromatic Substitution: Elimination–Addition
Electrophilic 1,2- and 1,4-Addition of X2 to 1,3-Butadiene