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Nutritional Supplementation for Obsessive-Compulsive Disorder: Protocol for a Systematic Review of Randomized

Pau Soldevila-Matías1,2,3,4, Joan Vicent Sánchez-Ortí1,2,3,4, Patricia Correa-Ghisays1,2,3,4

  • 1INCLIVA - Health Research Institute, Valencia, Spain.

JMIR Research Protocols
|November 18, 2025
PubMed
Summary

This systematic review evaluates nutritional supplements as adjunctive treatments for obsessive-compulsive disorder (OCD). Findings may guide the integration of these supplements to improve cognitive and psychiatric outcomes in OCD management.

Keywords:
cognitive functionnutritional supplementationobsessive-compulsive disorderquality of lifesystematic review

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Area of Science:

  • Neuroscience and Psychiatry
  • Nutritional Science
  • Evidence-Based Medicine

Background:

  • Obsessive-compulsive disorder (OCD) is a chronic condition with often incomplete symptom relief from standard treatments.
  • Nutritional supplements (vitamins, minerals, amino acids) show potential for adjunctive OCD therapy by influencing neurotransmitters and inflammation.

Purpose of the Study:

  • To systematically review and assess the comparative efficacy of nutritional supplements for OCD clinical outcomes.
  • To evaluate supplements as adjunctive treatments to standard pharmacological and psychological interventions for OCD.

Main Methods:

  • Systematic review protocol registered and developed.
  • Inclusion of randomized controlled trials comparing nutritional supplementation with standard OCD treatments.
  • Primary outcomes: cognitive performance, quality of life, psychiatric symptoms; Secondary outcomes: comorbidities.

Main Results:

  • Systematic searches conducted across major databases (MEDLINE, Embase, CENTRAL, ClinicalTrials.gov).
  • Study screening, full-text review, and data extraction are scheduled for completion by September 2025.
  • Risk of bias, study quality, and heterogeneity will be analyzed; association measures with 95% CIs calculated.

Conclusions:

  • The review aims to address treatment gaps in OCD by evaluating nutritional supplementation efficacy.
  • Findings may inform clinical practice regarding nutritional strategies for improving cognitive and psychiatric outcomes in OCD.
  • This protocol provides a framework for rigorous evidence synthesis to support integrated nutritional management in OCD.