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Updated: Jan 11, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
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Chemoselective Methionine Bioconjugation with Hydroxylamine Esters for Peptide/Protein Modifications

Man Li1,2, Tianyang Wang2, Linfeng Chen2

  • 1School of Pharmacy, Hubei University of Science and Technology, Xianning 437100, China.

Organic Letters
|November 18, 2025
PubMed
Summary

Researchers developed a green bioconjugation method using a new reagent that selectively modifies methionine in proteins and peptides. This simple approach offers a robust tool for peptide and protein modification under aqueous conditions.

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