Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration.

Area of Science:

• Biomaterials Science
• Oncology
• Regenerative Medicine

Background:

• Osteosarcoma is a primary bone cancer prevalent in children and adolescents.
• Current treatments involve surgery, leading to bone defects and risks of recurrence and metastasis.
• Biomaterials offer potential for bone regeneration and antitumor functions in osteosarcoma management.

Purpose of the Study:

• To review and categorize emerging biomaterial strategies for postsurgical osteosarcoma management.
• To analyze integrated approaches for simultaneous bone regeneration and tumor suppression.
• To assess the clinical translation potential and future challenges of these strategies.

Main Methods:

• Categorization of biomaterial strategies into three approaches: traditional bifunctional, enhanced antitumor bifunctional, and temporally controlled sequential.
• Critical analysis of cutting-edge biomaterials used in these strategies.
• Assessment of clinical translation barriers and future development challenges.

Main Results:

• Identified three distinct categories of integrated biomaterial strategies for osteosarcoma.
• Highlighted the shift from isolated osteogenic or antitumor functions to combined approaches.
• Evaluated the potential and limitations of current biomaterials for clinical application.

Conclusions:

• Integrated biomaterial strategies are crucial for simultaneously achieving bone regeneration and tumor suppression in osteosarcoma.
• Further research is needed to overcome technical barriers and facilitate clinical translation.
• Future development should focus on advanced, temporally controlled, and enhanced antitumor strategies.