Related Experiment Video
Updated: Jan 11, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
Published on: August 25, 2017
Evaluation of Clinical, Functional, and Radiological Characteristics of Chronic Obstructive Pulmonary Disease
Melike Yüksel Yavuz1, Ceyda Şahan1, Aylin Özgen Alpaydın2
1Department of Work and Occupational Diseases, Dokuz Eylül University Faculty of Medicine, İzmir, Türkiye.
Objective:
In recent years, non-smoking factors contributing to the etiology of Chronic Obstructive Pulmonary Disease (COPD) have gained attention. Occupational exposures are known to account for 14% of the COPD burden. In this study, we aimed to document the demographic, clinical, functional, and radiological characteristics of COPD patients who presented to the occupational diseases outpatient clinic with respect to their occupational exposure.
Materials And Methods:
The records of 33 patients with a final diagnosis of COPD, admitted to our outpatient clinic between 2013 and 2022, were analyzed retrospectively. The COPD diagnosis was made by an experienced occupational diseases specialist and two pulmonologists. Subgroups were created as non-occupational, work-exacerbated COPD, and occupational COPD.
Results:
All patients were male. The patients had a history of working in various sectors, including mining, metal processing, textiles, ceramics, construction, dental prosthesis manufacturing, cement production, food production, denim sandblasting, transport, and brick production. Six patients (18.2%) were diagnosed with non-occupational COPD, 16 (48.5%) with work-exacerbated COPD, and 11 (33.3%) with occupational COPD. There were no associated effects of smoking and dust exposure on forced expiratory volume in one second (FEV1) and FE1/FVC (Forced Vital Capacity) levels. Furthermore, 69.7% of the cases had more than one type of exposure (multiple exposure), and there was no statistically significant difference between occupational status and multiple or single exposure. No significant association was found between COPD-related radiological findings and the duration of exposure to silica dust, coal dust, metal dust, or organic dust.
Conclusion:
Vapors, dust, smoke, and gases in the workplace may contribute to COPD, even among non-smokers. Patients with suspected occupational exposure should be referred to occupational health and occupational diseases outpatient clinics.
Related Concept Videos
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

