Ultrasound-activatable transition metal complexes to potentiate sonodynamic therapy.

Area of Science:

• Biomedical Engineering
• Materials Science
• Oncology

Background:

• Sonodynamic therapy (SDT) is a non-invasive treatment using ultrasound to activate sonosensitisers, generating reactive oxygen species (ROS) for therapeutic effects.
• SDT offers advantages like deep tissue penetration and high precision, but its efficacy relies on effective ROS sonosensitisers.
• Transition metal complexes are gaining attention as potential sonosensitisers due to their high ROS generation efficiency and stability.

Purpose of the Study:

• To review recent advancements in transition metal complexes as ROS sonosensitisers for SDT.
• To explore their application in treating cancer, microbial infections, and cardiovascular diseases.
• To discuss strategies for enhancing sonosensitiser performance and integrating SDT with other therapies.

Main Methods:

• Literature review of recent studies on transition metal complexes in SDT.
• Analysis of design strategies for improving sonosensitiser performance.
• Examination of synergistic therapeutic approaches involving SDT.

Main Results:

• Transition metal complexes demonstrate significant potential as ROS sonosensitisers for SDT.
• These complexes show promise in preclinical studies for various diseases.
• Integration with other modalities can enhance therapeutic outcomes.

Conclusions:

• Transition metal complexes are promising agents for advancing SDT.
• Further research into design strategies and clinical translation is needed.
• Optimizing these sonosensitisers can improve patient outcomes in various diseases.