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A matrix metalloproteinase-responsive iridium(III)-based hydrogel for cancer cell-specific imaging and
Alex Man-Hei Yip1,2, Lawrence Cho-Cheung Lee1, Justin Shum1,2
1Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, P. R. China. bhkenlo@cityu.edu.hk.
Abstract:
A matrix metalloproteinase-sensitive iridium(III)-based hydrogel was designed to selectively deliver lysosome-targeting iridium(III) complexes into cancer cells in response to elevated enzyme activity. Upon light activation, the lysosome-localised complexes induced potent cytotoxicity and inhibited cell migration, demonstrating significant potential for cancer-specific imaging and targeted photodynamic therapy.
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