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High-affinity A/T-rich DNA binding with a dimeric bisbenzamidine.

David Bouzada1, Ananya Paul2, Mateo I Sánchez1

  • 1Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CiQUS), Departamento de Química Orgánica, Universidade de Santiago de Compostela, Santiago de Compostela 15782, Spain.

NAR Molecular Medicine
|November 19, 2025
PubMed
Summary

Researchers developed a new DNA minor groove binder by dimerizing a bisbenzamidine agent. This enhanced DNA-binding compound shows increased affinity for A/T-rich sites and higher antileishmanial activity.

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