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Cortical morphological alterations in methamphetamine-induced psychosis: a surface-based morphometry study.

Danlin Shen1, Dan Luo1, Mingfeng Lai1

  • 1Mental Health Center, West China Hospital of Sichuan University, No. 28 Dian Xin Nan Jie, Wuhou District, Chengdu, China.

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|November 19, 2025
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Summary
This summary is machine-generated.

Methamphetamine-induced psychosis (MAP) is linked to specific cortical thinning in temporal and limbic regions. These brain changes offer insights into the neurobiology of psychosis in methamphetamine use disorders (MUD).

Keywords:
MethamphetamineMethamphetamine-induced-psychosisSurface-based analysis

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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Neuroscience

Background:

  • Methamphetamine use disorder (MUD) affects millions, with a significant portion experiencing methamphetamine-induced psychosis (MAP).
  • The specific patterns of cortical atrophy in MAP remain largely uncharacterized.
  • Understanding these structural changes is crucial for developing targeted interventions.

Purpose of the Study:

  • To investigate the distinct cortical atrophy patterns in individuals with MUD, differentiating between those with and without psychotic symptoms (MAP vs. MA).
  • To identify specific brain regions affected by cortical thinning and volume reduction in MAP.
  • To explore correlations between observed brain structural changes and clinical variables like craving severity.

Main Methods:

  • Utilized high-resolution T1-weighted MRI scans from 94 male MUD patients (62 MA, 32 MAP) and 61 healthy controls (HCs).
  • Employed surface-based morphological (SBM) analysis with FreeSurfer to assess cortical thickness and volume differences.
  • Correlated structural brain changes with clinical assessments, including craving severity.

Main Results:

  • MAP patients exhibited significant cortical thinning in the left superior temporal gyrus (STG) and right rostral anterior cingulate cortex (rACC) compared to both HCs and MA.
  • The MA group showed decreased cortical volume in the left caudal middle frontal gyrus (cMFG) and superior parietal cortex (SPC) relative to HCs.
  • A positive correlation was found between left cMFG volume and craving severity (VAS score) in the MUD cohort.

Conclusions:

  • MAP is associated with distinct, region-specific cortical thinning in temporal and limbic areas, indicating a structural basis for psychotic symptoms.
  • These findings enhance our understanding of the neurobiological underpinnings of MAP.
  • The identified structural differences may guide the development of future therapeutic strategies for MUD and MAP.