Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

3.9K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
3.9K
Comparing the Survival Analysis of Two or More Groups01:20

Comparing the Survival Analysis of Two or More Groups

525
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
525
Cancer Survival Analysis01:21

Cancer Survival Analysis

624
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
624

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimized phenotype definitions boost GWAS power.

PLoS computational biology·2026
Same author

BioMADE: Predicting Torsades de Pointes from molecular structures through biologically informed representations.

bioRxiv : the preprint server for biology·2026
Same author

Marital status and post-radical prostatectomy outcomes: results from the SEARCH database.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer·2026
Same author

Toward scalable early cancer detection: evaluating EHR-based predictive models against traditional screening criteria.

NPJ precision oncology·2026
Same author

Diet in Prostate Cancer: Promising Side Dish or Main Course?

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2026
Same author

Patient Participation in Consultations for Clinically Localized Prostate Cancer: Erratum.

The Journal of urology·2026
Same journal

Notice of Retraction. Ren Y, et al. Personality Traits and Social Isolation in Older Adults. JAMA Netw Open. 2026;9(5):e269569.

JAMA network open·2026
Same journal

Error in Grant Number in Funding/Support Section.

JAMA network open·2026
Same journal

The Supplementary Role of Friends in Caregiving Networks.

JAMA network open·2026
Same journal

Urbanicity, Neighborhood Conditions, and Dementia Mortality.

JAMA network open·2026
Same journal

Equity and Cancer Survival Among Veterans Health Administration Patients: A Systematic Review and Meta-Analysis.

JAMA network open·2026
Same journal

Limbic System Microstructure in Neonates With Antenatal Opioid Exposure.

JAMA network open·2026
See all related articles

Related Experiment Video

Updated: Jan 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K

Racial Differences in Adverse Events After Androgen Deprivation in Veterans With Prostate Cancer.

Nadine A Friedrich1,2,3, Jessica L Janes4, Joshua Parrish4

  • 1Department of Urology, Cedars-Sinai Medical Center, Los Angeles, California.

JAMA Network Open
|November 19, 2025
PubMed
Summary
This summary is machine-generated.

Androgen deprivation therapy (ADT) increases cardiovascular and bone risks in prostate cancer patients across all races. While risks slightly differ between Black and White patients, monitoring is crucial for all.

More Related Videos

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.8K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

8.9K

Related Experiment Videos

Last Updated: Jan 6, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.7K
Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy
09:49

Isolation of Adipose Derived Regenerative Cells for the Treatment of Erectile Dysfunction Following Radical Prostatectomy

Published on: December 28, 2021

3.8K
Retzius-Sparing Robot-Assisted Radical Prostatectomy
12:10

Retzius-Sparing Robot-Assisted Radical Prostatectomy

Published on: May 19, 2022

8.9K

Area of Science:

  • Oncology
  • Cardiovascular Medicine
  • Bone Health

Background:

  • Androgen deprivation therapy (ADT) is a common prostate cancer (PC) treatment.
  • ADT is associated with adverse events like cardiac issues and osteoporosis.
  • Racial disparities in ADT's adverse event associations are not well understood.

Purpose of the Study:

  • To evaluate the association between ADT and cardiovascular and bone-related adverse events.
  • To determine if these associations differ across racial groups in PC patients.

Main Methods:

  • Retrospective, nationwide, population-based cohort study using Veterans Affairs Health Care System data (2001-2021).
  • Included 790,916 veterans with PC, excluding specific treatment groups and those with missing race data.
  • Used Cox models to assess ADT's association with time-to-event outcomes, stratified by race.

Main Results:

  • ADT significantly increased risks for cardiovascular events (HR 1.16), bone fractures (HR 1.59), and osteoporosis (HR 2.73) across all races.
  • Among Black patients vs. White patients, ADT showed slightly lower excess risk for cardiovascular events and fractures but higher risk for osteoporosis.
  • Hispanic patients and other races showed risk associations similar to White patients.

Conclusions:

  • ADT is linked to increased cardiovascular and bone risks in prostate cancer patients of all races.
  • While minor differences exist between Black and White patients, overall risk associations are comparable.
  • Highlights the necessity for vigilant monitoring and risk mitigation strategies for all patients undergoing ADT.