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Polymeric Sunscreen via the Biginelli Reaction and Sequential C-S Coupling Reaction for UV Protection
Yuhang Jiang1,2, Xinxin Wu2, Wenqian Chen2,3
1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu 214122, P. R. China.
None:
Excessive ultraviolet (UV) radiation poses significant adverse health effects on humans, underscoring the critical need for novel sunscreen agents. Conventional small-molecule UV filters often suffer from drawbacks such as percutaneous absorption and environmental toxicity. In this work, we report the design and synthesis of novel monomers bearing both dihydropyrimidin-2(1H)-thione (DHPMT) and dihydrothiazole moieties through the integration of the Biginelli reaction and sequential C-S coupling reaction, followed by the copolymerization with poly(ethylene glycol) methyl ether methacrylate (PEGMA-950) to yield new functional polymers. The resulting polymers exhibited low cytotoxicity. Importantly, in vivo evaluation in a murine model demonstrated their effective protection against UV-induced skin damage. This work underscores the synthetic versatility of this two-step reaction in the development of UV-shielding polymeric materials and offers a promising strategy for engineering multifunctional polymers via multicomponent reaction platforms.
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