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Tracking Systemic Inflammation in Allergic Rhinitis with Immune-Inflammation Markers.

Mustafa Ilker Inan1, Yasemin Akgul Balaban2, Fevzi Demirel2

  • 1Department of Immunology and Allergy, Gulhane Training and Research Hospital, Ankara, Turkey, m.ilkerinan@gmail.com.

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|November 19, 2025
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Summary
This summary is machine-generated.

Systemic inflammation markers like platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV) are elevated in allergic rhinitis (AR). These markers, along with neutrophil-to-lymphocyte ratio (NLR), improve with nasal corticosteroid therapy.

Keywords:
Allergic rhinitisInflammationNasal corticosteroidsNeutrophil-to-lymphocyte ratioPan-immune-inflammation valuePlatelet-to-lymphocyte ratioSCUBESystemic immune-inflammation index

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Area of Science:

  • Immunology
  • Clinical Medicine
  • Biomarker Discovery

Background:

  • Allergic rhinitis (AR) is characterized by nasal inflammation but also involves systemic inflammatory responses.
  • Evaluating systemic inflammation biomarkers is crucial for understanding and managing AR.

Purpose of the Study:

  • To assess the diagnostic and monitoring utility of systemic inflammation biomarkers in AR.
  • To investigate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and serum SCUBE levels in AR patients.

Main Methods:

  • A prospective study involving 88 AR patients and 50 healthy controls.
  • AR patients received nasal corticosteroid (NCS) therapy.
  • Assessed symptom severity (VAS, CARAT) and measured NLR, PLR, SII, PIV, and SCUBE levels pre- and post-treatment.

Main Results:

  • AR patients showed significantly higher PLR, SII, and PIV compared to controls.
  • Nasal corticosteroid therapy led to significant clinical improvement and decreased NLR, PLR, and SII levels.
  • PIV, SII, and PLR demonstrated potential as diagnostic biomarkers for AR.

Conclusions:

  • PLR, SII, and PIV are elevated in AR, indicating a significant systemic inflammatory component.
  • NLR, PLR, and SII levels decrease with effective AR treatment.
  • SII and PIV are promising, accessible biomarkers for assessing and monitoring inflammation in allergic rhinitis.