Related Experiment Video
Updated: Jan 11, 2026
08:29
An Open Source Technology Platform to Manufacture Hydrogel-Based 3D Culture Models in an Automated and Standardized Fashion
Published on: March 31, 2022
4.9K
[Retractions in biomedical research (2000-present): current status]
Jacques Haiech1, Camille Noûs1, Claude Forest1
1Équipe pédagogique éthique, déontologie et intégrité scientifique (EPEDIS), Université Paris Cité, UFR des sciences fondamentales et biomédicales, Campus Saint Germain des Près, Paris, France.
Medecine Sciences : M/S
|November 19, 2025
Summary
Biomedical research retractions surged since 2000, driven by fraud and misconduct. Strengthening scientific integrity and reforming publishing practices are crucial for accurate scientific progress.
Area of Science:
- Biomedical research
- Bibliometrics
- Scientific publishing
Background:
- Exponential increase in biomedical research retractions since the early 2000s.
- Growing structural tensions within the global scientific system.
- Retractions serve as indicators of systemic issues.
Purpose of the Study:
- To critically synthesize retractions between 2000 and 2025.
- To analyze bibliometric data and socio-institutional factors.
- To identify patterns and causes of retractions.
Main Methods:
- Bibliometric data analysis.
- Socio-institutional analyses.
- Distinguishing between honest error and scientific misconduct.
Main Results:
- Differentiated geographical dynamics in retraction rates.
- Institutionalization of fraud and misconduct.
- Typical profiles of retracted authors (male, hyper-productive, poorly supervised).
- Majority of retractions linked to fraud, plagiarism, or manipulation.
- Continued citation of retracted articles despite strengthened self-correction.
Conclusions:
- Scientific self-correction mechanisms are imperfect.
- Urgent need to rethink academic evaluation criteria.
- Strengthening scientific integrity and editorial governance is essential.
- Retractions signal a need for profound reform in scientific publishing practices.
Related Concept Videos
01:16Clot Retraction and Fibrinolysis
8.3K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
8.3K
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
387
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
387
01:19Pharmacovigilance
1.6K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.6K
02:58Regulated Protein Degradation
8.7K
It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
Protein degradation plays two important roles in the cells. It helps to protect cells from misfolded or damaged proteins before they lead to a...
8.7K
02:57Real Time RT-PCR
64.4K
Real-time reverse transcription-polymerase chain reaction, or Real-time RT-PCR, is an analytical tool used to determine the expression level of target genes. The method involves converting mRNA to complementary DNA with the help of an enzyme known as reverse transcriptase, followed by the PCR amplification of the cDNA. These two processes can be performed simultaneously in a single tube or separately as a two-step reaction.
The real-time quantification of the number of amplified products is...
The real-time quantification of the number of amplified products is...
64.4K
01:56Ethics in Research
25.4K
Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
25.4K