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Antimuscarinics in multiple sclerosis: A systematic review

Afra Darvishi1, Sina Pakkhesal2, Ali Alipour1

  • 1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.

Multiple Sclerosis and Related Disorders
|November 19, 2025
PubMed
Summary

Antimuscarinic drugs (AMs) effectively treat lower urinary tract symptoms (LUTS) in multiple sclerosis (MS) patients, improving quality of life. However, AMs may cause cognitive deficits, dry mouth, and dizziness, requiring careful consideration in MS management.

Keywords:
AnticholinergicAntimuscarinicMultiple sclerosisNocturiaOveractive bladderUrinary incontinenceUrinary tractUrinary urgency

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