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Splenic Artery Aneurysm Associated with Myelofibrosis Managed by Coil Embolization

Itaru Watanabe1, Tatsuya Konishi1,2, Jun Yamanouchi1,2

  • 1Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|November 19, 2025
PubMed

Insights

Myelofibrosis can lead to splenic artery aneurysms. JAK inhibitor therapy helped manage spleen size, enabling safe treatment for this rare vascular complication.

Area of Science:

  • Hematology
  • Vascular Surgery
  • Oncology

Background:

  • Myelofibrosis (MF) is a myeloproliferative neoplasm often associated with splenomegaly.
  • Splenic artery aneurysms (SAA) are rare vascular complications in MF patients.
  • The JAK2 V617F mutation is common in secondary MF.

Purpose of the Study:

  • To report a case of secondary MF with SAA.
  • To illustrate the management of SAA in an MF patient.
  • To explore the role of JAK inhibitor therapy in facilitating endovascular treatment.

Main Methods:

  • Case report of a 74-year-old woman with secondary MF and SAA.
  • Treatment with Ruxolitinib to reduce splenomegaly and constitutional symptoms.
  • Spleen-preserving coil embolization for SAA intervention.

Main Results:

  • Ruxolitinib therapy effectively reduced splenomegaly and improved symptoms.
  • The patient's condition was optimized for safe coil embolization.
  • Successful spleen-preserving endovascular treatment of SAA was achieved.

Conclusions:

  • MF may be associated with aneurysm formation.
  • JAK inhibitor therapy can optimize patients for safe endovascular procedures.
  • This case highlights a potential management strategy for SAA in MF patients.
Keywords:
coil embolizationmyelofibrosisruxolitinibsplenic artery aneurysmsplenomegaly

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