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Published on: February 16, 2011
From pill to purpose: Rethinking outcomes evaluation through patient-centered metrics in pharmacoepidemiology and
Mohamed AbdElrahman1, Mohammed D Al-Rekabi2, Mohamed E A Abdelrahim3
1Clinical Pharmacy Department, College of Pharmacy, Al-Mustaqbal University, Babylon, 51001, Iraq; Clinical Pharmacy Department, Badr University Hospital, Faculty of Medicine, Helwan University, Egypt.
None:
Despite progress in medication and evidence-based protocols, a disparity persists between clinical outcomes and patients lived experiences. Conventional pharmacoepidemiologic metrics-such as biomarker targets or hospitalization rates-frequently do not capture what patients prioritize: functionality, autonomy, and quality of life. This article promotes a transition to patient-centered measures, such as patient-reported outcomes (PROs), goal attainment scaling (GAS), and behavioral adherence models. By incorporating these approaches into research and practice, healthcare systems can more effectively assess therapy efficacy in real-world settings. The opinion emphasizes data that supports Patient-Reported Outcomes (PROs) and Goal Attainment Scaling (GAS), addresses implementation problems, and advocates for the realignment of assessment systems towards purpose-driven care. Ultimately, aligning outcome evaluation with patients' objectives promotes relevance, equity, and participation in chronic disease management-prompting pharmacoepidemiology to evaluate not only the efficacy of pharmaceuticals but also their meaningful impact on the lives of users.
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