Postoperative Pain Treatment After Pancreatic Surgery. A Protocol for Systematic Review With Meta-Analysis and Trial...

Area of Science:

• Surgery
• Anesthesiology
• Evidence-Based Medicine

Background:

• Pancreatic surgeries like pancreatoduodenectomy, distal pancreatectomy, and total pancreatectomy are complex and cause significant pain.
• Effective postoperative pain management is vital for patient mobility, reduced hospital stays, and fewer complications.
• Current optimal pain management strategies and the risks/benefits of various analgesics are not well-defined.

Purpose of the Study:

• To systematically review the benefits and harms of analgesic interventions in adult patients undergoing major pancreatic resections.
• To synthesize evidence on pain management following total pancreatectomy, pancreatoduodenectomy, and distal pancreatectomy.

Main Methods:

• Systematic review and meta-analysis adhering to PRISMA guidelines.
• Searched Medline, EMBASE, and CENTRAL for randomized clinical trials comparing analgesic interventions to controls.
• Assessed risk of bias using ROB2, conducted trial sequential analysis, and evaluated evidence quality with GRADE.

Main Results:

• (Pending completion of the review) This section will detail the findings from the meta-analysis regarding the efficacy and safety of different analgesic interventions.
• (Pending completion of the review) Results will be presented with GRADE assessments of evidence quality.

Conclusions:

• (Pending completion of the review) The review will provide insights into the optimal analgesic strategies for pancreatic surgery.
• (Pending completion of the review) Findings will inform clinical practice regarding the benefits and harms of various pain management options to improve patient outcomes.