Cross-lagged analysis of interdependence and psychological symptom clusters in postpartum women: A prospective study

Yunjuan Ji1, Lili Xue, Liping Chen

  • 1Department of Obstetrics, The First People's Hospital of Nantong, Nantong City, Jiangsu Province, China.

Medicine
|November 20, 2025
PubMed

The aim of this study is to investigate the longitudinal interaction mechanism between interdependence and clusters of psychological emotional symptoms in postpartum women. Three waves of follow-up assessments were conducted on 389 postpartum women at T1 (before discharge), T2 (42 days post-delivery), and T3 (3 months post-delivery). The assessments utilized the general information questionnaire, the 10-item Connor-Davidson resilience scale (CD-RISC-10), the Edinburgh Postnatal depression scale (EPDS), the post-traumatic stress disorder (PTSD) Checklist-Civilian version (PCL-C-7), and the mutuality scale (MS) to evaluate resilience, depression, PTSD, and marital mutuality. Cross-lagged panel analysis was employed to examine the causal paths between variables over time. The autoregressive effect indicated that all variables exhibited significant temporal stability (β = 0.50-0.65, P < .001), with resilience demonstrating the highest stability (T1 → T2: β = 0.65; T2 → T3: β = 0.62); The protective pathway revealed that resilience significantly enhanced the subsequent marital relationship (T1 → T2: β = 0.28; T2 → T3: β = 0.26), and a negative marital relationship predicted depressive symptoms (T2 → T3: β = -0.22). Resilience also directly reduced the risk of depression (T2 → T3: β = -0.23); and Inter-symptom reinforcement showed that depression increased the risk of subsequent PTSD (T1 → T2: β = 0.38; T2 → T3: β = 0.42), and PTSD exacerbation was followed by depression (T2 → T3: β = 0.37). Psychological resilience indirectly ameliorates emotional symptoms by bolstering marital relationships, while depression and PTSD establish a bidirectional vicious cycle. The research endorses a three-tiered prevention strategy that focuses on fostering resilience and intervening in partner relationships during the early postpartum period.

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