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Pyoderma gangrenosum (PG) in infants is rare and often misdiagnosed. Early recognition and corticosteroid treatment are key for favorable outcomes in infantile PG cases.

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Area of Science:

  • Dermatology
  • Pediatrics
  • Pathology

Background:

  • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis.
  • Infantile PG is frequently misdiagnosed due to overlapping symptoms with infectious and inflammatory conditions.
  • Literature on neonatal and infantile PG is limited.

Purpose of the Study:

  • To review existing literature on neonatal and infantile PG.
  • To present a case of infantile PG.
  • To emphasize the importance of recognizing PG in infants.

Main Methods:

  • Literature review.
  • Case presentation of a 6-month-old male with ulcerative lesions.
  • Histopathological analysis revealing neutrophilic infiltrate.
  • Comprehensive workup for underlying conditions.

Main Results:

  • The patient presented with rapidly progressive ulcerative lesions on the face, scalp, extremities, and hard palate.
  • Histopathology confirmed a dense dermal neutrophilic infiltrate.
  • Extensive workup was unremarkable for other systemic diseases.
  • The patient achieved rapid and complete remission with systemic corticosteroid monotherapy.

Conclusions:

  • Infantile PG can present with rapidly progressive ulcerative lesions.
  • Corticosteroids are effective as first-line therapy for infantile PG.
  • Prompt recognition and treatment are crucial for favorable outcomes in infantile PG, even without systemic disease.