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Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

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Chronic Kidney Disease I: Introduction01:25

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Chronic Kidney Disease II: Clinical Manifestations01:24

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Updated: May 9, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
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Published on: April 12, 2021

Skin Disorders in Kidney Disease: Core Curriculum 2026.

Colleen M Glennon1, Sagar U Nigwekar2, Daniela Kroshinsky1

  • 1Department of Dermatology, School of Medicine, Duke University, Durham, North Carolina.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|November 18, 2025
PubMed
Summary
This summary is machine-generated.

Patients with chronic kidney disease (CKD) frequently experience debilitating skin disorders like CKD-associated pruritus (CKD-aP). Understanding these conditions is crucial for improving patient quality of life.

Keywords:
Acquired perforating disordercalcinosis cutiscalciphylaxischronic kidney diseasecutaneous lupuspruritusskin disordersvasculitis

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Area of Science:

  • Nephrology
  • Dermatology

Background:

  • Skin disorders are prevalent in chronic kidney disease (CKD) patients, significantly impacting quality of life.
  • Common pathophysiological mechanisms include uremic solute accumulation, metabolic disturbances, and inflammation.

Purpose of the Study:

  • To review common skin disorders associated with CKD.
  • To highlight the clinical significance and presentation of these conditions for healthcare providers.

Main Methods:

  • Literature review of skin disorders in CKD patients.
  • Synthesis of information on prevalence, pathophysiology, and clinical features.

Main Results:

  • Key CKD-associated skin conditions include CKD-associated pruritus (CKD-aP), acquired perforating disorder (APD), calcinosis cutis, calciphylaxis, cutaneous lupus, and vasculitis.
  • CKD-aP affects 40% of dialysis patients and 20% of earlier CKD stage patients.
  • APD, calcinosis cutis, calciphylaxis, lupus, and vasculitis present with distinct dermatological manifestations.

Conclusions:

  • Clinicians must be aware of the diverse skin manifestations in CKD.
  • Early recognition and management of these dermatological conditions are essential for patient care.