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Infantile Pyoderma Gangrenosum: A Rare and Challenging Case Presentation With an Updated Literature Review

Alexis Tracy1, Kali Morrissette1, Daniela Kroshinsky1

  • 1Department of Dermatology, Duke University, Durham, North Carolina, USA.

Pediatric Dermatology
|November 20, 2025
PubMed

Insights

Pyoderma gangrenosum (PG) in infants is rare and often misdiagnosed. Early recognition and corticosteroid treatment are key for favorable outcomes in infantile PG cases.

Area of Science:

  • Dermatology
  • Pediatrics
  • Pathology

Background:

  • Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis.
  • Infantile PG is frequently misdiagnosed due to overlapping symptoms with infectious and inflammatory conditions.
  • Literature on neonatal and infantile PG is limited.

Purpose of the Study:

  • To review existing literature on neonatal and infantile PG.
  • To present a case of infantile PG.
  • To emphasize the importance of recognizing PG in infants.

Main Methods:

  • Literature review.
  • Case presentation of a 6-month-old male with ulcerative lesions.
  • Histopathological analysis revealing neutrophilic infiltrate.
  • Comprehensive workup for underlying conditions.

Main Results:

  • The patient presented with rapidly progressive ulcerative lesions on the face, scalp, extremities, and hard palate.
  • Histopathology confirmed a dense dermal neutrophilic infiltrate.
  • Extensive workup was unremarkable for other systemic diseases.
  • The patient achieved rapid and complete remission with systemic corticosteroid monotherapy.

Conclusions:

  • Infantile PG can present with rapidly progressive ulcerative lesions.
  • Corticosteroids are effective as first-line therapy for infantile PG.
  • Prompt recognition and treatment are crucial for favorable outcomes in infantile PG, even without systemic disease.

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