Analysis and Identification of Genetic Predisposition and Clinical Risk Factors for Lung Cancer: A Regional Genetic...

Area of Science:

• Genetics
• Oncology
• Epidemiology

Background:

• Lung cancer incidence is increasing in Taiwan, particularly among women.
• Family history and genetic predisposition are significant risk factors.
• The predictive utility of polygenic risk scores (PRS) in diverse populations requires validation.

Purpose of the Study:

• To evaluate the PGS000070 polygenic risk score model in a Taiwanese population.
• To assess the association between PGS000070 and lung cancer risk across genders.
• To explore the relationship between PRS and clinical outcomes, including surgical procedures.

Main Methods:

• Retrospective analysis of 54,962 participants from the Taiwan Precision Medicine Initiative.
• Genotyping of 1,673 lung cancer patients using the Affymetrix Genome-Wide TWB 2.0 SNP array.
• Logistic regression and subgroup analyses to determine the association between PGS000070 and lung cancer risk.

Main Results:

• Higher PGS000070 scores significantly correlated with increased lung cancer risk in both males and females.
• Females in the highest PRS quartile (Q4) had a 2.017-fold increased odds of lung cancer compared to the lowest quartile (Q1).
• Individuals with higher PRS scores exhibited a greater proportion of surgeries, including lobectomy and lymph node dissection.

Conclusions:

• PGS000070 demonstrates significant predictive value for lung cancer risk in the Taiwanese population.
• Elevated polygenic risk scores are associated with increased likelihood of surgical intervention.
• Further research is warranted to investigate the complex interplay of genetic factors, sex, and comorbidities in lung cancer development.