Related Experiment Video
Updated: Jan 10, 2026
07:50
Utilization of Ultrasound Guided Tissue-directed Cellular Implantation for the Establishment of Biologically Relevant Metastatic Tumor Xenografts
Published on: May 25, 2018
8.8K
Mesoblastic nephroma in a young Entlebucher Mountain Dog
Sandra Lockow1, Layla Johannsen1, Nane Schulz1
1Department of Pathology, University of Veterinary Medicine Hannover, Buenteweg 17, D-30559, Hannover, Germany.
Journal of Comparative Pathology
|November 20, 2025
Summary
A rare congenital mesoblastic nephroma was surgically removed from a young dog. This successful treatment resulted in the dog remaining healthy for three years post-surgery.
Area of Science:
- Veterinary Pathology
- Canine Oncology
- Surgical Oncology
Background:
- Gastrointestinal disease in dogs can indicate serious underlying conditions.
- Renal masses in young dogs are uncommon but require thorough investigation.
- Congenital mesoblastic nephroma is a rare kidney tumor.
Purpose of the Study:
- To diagnose and treat a suspected kidney tumor in a young Entlebucher Mountain Dog.
- To characterize the histological and immunohistochemical features of the renal tumor.
- To report the long-term outcome following surgical intervention.
Main Methods:
- Clinical examination and abdominal ultrasonography.
- Surgical nephrectomy and ovariohysterectomy.
- Histopathological and immunohistochemical analysis (vimentin, S-100 protein, p75NTR).
Main Results:
- A mesenchymal tumor consistent with congenital mesoblastic nephroma was identified.
- Neoplastic cells expressed vimentin, S-100 protein, and p75NTR.
- The dog showed no signs of recurrence three years after surgery.
Conclusions:
- Surgical management can be curative for congenital mesoblastic nephroma in dogs.
- The expression of p75NTR in this tumor is a novel finding requiring further investigation.
- This case highlights the importance of prompt diagnosis and surgical intervention for renal masses in dogs.
