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Updated: Jan 10, 2026

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance
Published on: November 7, 2025
Current and Upcoming Trials in Localized Prostate Cancer
Landan P MacDonald1, Andrew M Fang1, Chad Tang2
1Department of Urology, Unit 1373, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
This review summarizes recent advances in localized prostate cancer (PCa) diagnosis and management. It highlights new treatments and ongoing trials to improve patient outcomes and reduce side effects.
Area of Science:
- Oncology
- Urology
Background:
- Localized prostate cancer (PCa) management is evolving rapidly.
- Numerous clinical trials are underway, influencing treatment strategies.
Purpose of the Study:
- To review recent phase III trial findings for localized PCa.
- To update evidence-based management and discuss emerging innovations.
- To synthesize current research for optimizing patient care.
Main Methods:
- Review of recently completed phase III clinical trials.
- Analysis of ongoing studies in localized prostate cancer.
- Synthesis of evidence-based management approaches.
Main Results:
- Advances in local therapy, lymph node management, and imaging are noted.
- Systemic treatments and quality-of-life considerations are improving outcomes.
- Emerging innovations show potential for enhanced patient care.
Conclusions:
- Optimizing outcomes while minimizing toxicity is achievable with current advances.
- Evidence-based approaches and new innovations are key to improving localized PCa care.
- Continued research and clinical trials are vital for future progress.
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