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Microfabricated Post-Array-Detectors mPADs: an Approach to Isolate Mechanical Forces
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Pillar arrays as tunable interfacial barriers for microphysiological systems.

Ishan Goswami1,2, Yongdeok Kim1,2,3, Gabriel Neiman1

  • 1Department of Bioengineering, University of California, Berkeley, CA, USA.

Communications Engineering
|November 20, 2025
PubMed
Summary
This summary is machine-generated.

We developed a novel pillar array barrier for microphysiological systems (MPS). This tunable interface precisely controls diffusion for better drug screening and disease modeling in engineered tissues.

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Materials Science

Background:

  • Traditional microphysiological system (MPS) barriers like membranes have limitations in pore size consistency, fabrication complexity, and scalability.
  • Existing barrier designs lack tunability, hindering precise control over diffusion and cell behavior within microfluidic devices.

Purpose of the Study:

  • To design and fabricate a novel circular pillar array as a tunable interfacial barrier for microfluidic microphysiological systems (MPS).
  • To overcome the limitations of traditional barriers by offering precise control over pore size, porosity, and hydraulic resistance.
  • To demonstrate the utility of this tunable barrier for engineering physiologically relevant microtissues and models for drug screening and disease modeling.

Main Methods:

  • Fabrication of a circular pillar array with adjustable pillar dimensions.
  • Characterization of barrier properties, including pore size, porosity, and hydraulic resistance.
  • Engineering of cardiac microtissues and a heterotypic model with vasculature within the MPS device.

Main Results:

  • The pillar array provides precise control over barrier properties through simple modifications of pillar dimensions.
  • Demonstrated successful engineering of physiologically relevant cardiac microtissues and a vascularized heterotypic model.
  • The tunable barrier effectively mimics in vivo diffusion and facilitates cell aggregation for tissue formation.

Conclusions:

  • The developed pillar array serves as a versatile and tunable interfacial barrier for microfluidic MPS.
  • This technology enables advanced applications in drug screening, permeability studies, and disease modeling by allowing comparisons with and without vasculature.
  • The scalable and tunable design offers significant potential for creating more accurate and predictive in vitro models.