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Updated: Jan 10, 2026

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
X-LDR: an atlas of linkage disequilibrium across species
Tian-Neng Zhu1,2,3, Xing Huang4, Meng-Yuan Yang5
1Department of Genetic and Genomic Medicine, Center for Laboratory Medicine, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
Abstract:
To reach a genomic scale illustration for linkage disequilibrium (LD), we introduce X-LDR, a stochastic algorithm for biobank-scale data ([Formula: see text], n the sample size, m the number of SNPs, and B iterations). X-LDR can scale the entire genome to high-resolution LD grids, such as nearly 9 million LD grids for UK Biobank ([Formula: see text] and [Formula: see text] million). Various characteristics of LD are discovered in terms of their biological annotation. We also present an unprecedented LD atlas for 25 reference populations that contours the diversity of interspecies LD. The algorithms have been implemented in C++.
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