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Urinary Bladder01:23

Urinary Bladder

3.0K
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
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Anatomy of the Genitourinary System II: Bladder and Urethra01:19

Anatomy of the Genitourinary System II: Bladder and Urethra

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The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
1.3K
The Micturition Reflex01:26

The Micturition Reflex

2.4K
Urination, or micturition involves the coordination of the bladder's detrusor muscle and two sphincters to ensure controlled bladder emptying.
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
2.4K
Nursing Assessment of the Genitourinary System II: Inspection and Palpation01:26

Nursing Assessment of the Genitourinary System II: Inspection and Palpation

713
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
713
Ureters01:22

Ureters

1.4K
The ureters are retroperitoneal tubes located on either side of the vertebral column. They are responsible for transporting urine from each kidney to the urinary bladder. These tubes have thick walls and are approximately 25-30 cm long. Their diameter is around 10 mm at the renal pelvis, gradually narrowing to 1 mm as the ureter obliquely enters the posterior bladder wall through the ureteric orifices. The shape of these orifices is slit-like, which helps to prevent urine backflow toward the...
1.4K
Imaging Studies VI: Voiding Cystourethrography and Cystography01:22

Imaging Studies VI: Voiding Cystourethrography and Cystography

1.1K
Voiding Cystourethrography (VCUG) and Cystography are specialized radiographic procedures used to examine the structure and function of the bladder and urethra.Voiding Cystourethrography (VCUG)A Voiding Cystourethrogram (VCUG) is a diagnostic imaging procedure that assesses the anatomy and function of the lower urinary tract. It focuses on the bladder, bladder neck, and urethra, helping detect abnormalities such as vesicoureteral reflux (VUR)—the backward or reverse flow of urine into the...
1.1K

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Related Experiment Video

Updated: Jan 10, 2026

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice
11:46

Urinary Bladder Distention Evoked Visceromotor Responses as a Model for Bladder Pain in Mice

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Bladder Trigone as a Sensory Hub: A Narrative Review.

Takuya Sadahira1,2, Yuki Maruyama1, Yosuke Mitsui1

  • 1Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JPN.

Cureus
|November 21, 2025
PubMed
Summary

The bladder trigone is a key sensory area in the lower urinary tract. Understanding its specialized nerve pathways is crucial for treating bladder dysfunction and pain.

Keywords:
bladder trigonebotulinum toxinlower urinary tract symptomssensory afferentsvaricosities

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Area of Science:

  • Neuroscience
  • Urology
  • Cell Biology

Background:

  • The bladder trigone, a distinct lower urinary tract region, possesses unique sensory innervation.
  • Dysregulation of trigonal signaling contributes to lower urinary tract symptoms (LUTS) like urgency and pain.
  • The precise structural and functional basis of trigonal sensory signaling remains incompletely understood.

Purpose of the Study:

  • To synthesize current evidence on trigonal afferent organization and sensory signaling.
  • To integrate anatomical, molecular, and functional data on trigonal sensory pathways.
  • To provide a comprehensive perspective on the trigone's role in bladder sensation and dysfunction.

Main Methods:

  • Review of anatomical mapping, receptor profiling, and electrophysiological characterization.
  • Integration of data on mechanotransduction, purinergic, peptidergic, and TRP signaling.
  • Analysis of translational research and functional assays in aging, inflammation, and disease models.

Main Results:

  • Identified three principal afferent classes in the trigone with specific molecular markers (P2X3, TRPV1, CGRP, SP, PIEZO1/2, ASICs).
  • Observed high expression of PIEZO2, P2RX3, and Nav1.8 in trigeminal dorsal root ganglion neurons.
  • Demonstrated that aging, inflammation, and neurotrophic factors drive afferent plasticity underlying abnormal bladder sensation.

Conclusions:

  • The bladder trigone acts as a critical sensory hub integrating neuronal, urothelial, and immune signals.
  • Understanding trigonal specialization can inform targeted therapies for sensory urgency and bladder dysfunction.
  • Early clinical trials with P2X3 antagonists and TRPV1 inhibitors show promise for symptomatic relief.