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Copper-Catalyzed Sulfinylation of Boronic Acids with Sulfinates
Huiling Ma1, Xinhua Wang1, Shujing Ma1
1School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies, Taizhou University, 1139 Shifu Avenue, Taizhou 318000, China.
None:
A copper-catalyzed sulfinylation of boronic acids with sulfinates was achieved to access a range of aryl/alkenyl sulfoxides. Dialkyl dicarbonates served as the key activator, effectively promoting the desired sulfinylation process and suppressing the undesired pathway to the thiosulfonate byproduct. Preliminary mechanistic studies indicated that this transformation favors a copper-mediated nucleophilic substitution over a Suzuki-type cross-coupling process. This protocol paves the way for the metal-catalyzed establishment of a C-S(=O) bond from readily available sulfinates.
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