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Published on: May 16, 2019
Clinical practice guidelines for the administration of third-generation anti-seizure medications
Xintong Wu1, Yangmei Chen2, Li Feng3
1Department of Neurology, West China Hospital of Sichuan University, Chengdu, 610041, China.
Purpose:
This guideline evaluated previous clinical studies that examined the use of third-generation antiseizure medications (ASMs) to treat epilepsy in order to provide treatment recommendations from a clinical practice perspective, thus aiming to enhance clinicians' understanding of these drugs and improve the standardization of clinical treatment.
Methods:
A systematic literature search was conducted to identify studies that examined third-generation ASMs. The included literature was rated using the 2011 Oxford Centre for Evidence-based Medicine (OCEBM) levels of evidence, and recommendations were formulated. The strength of the recommendations was determined based on the evidence level and drug safety profiles.
Results:
This guideline examines 10 third-generation ASMs: pregabalin (PGB), rufamide (RFN), lacosamide (LCM), perampanel (PER), eslicarbazepine (ESL), brivaracetam (BRV), stripentol (STP), cannabidiol (CBD), cenobamate (CNB) and fenfluramine (FFA). Recommendations were developed for 13 clinical questions.
Conclusion:
This guideline provides a detailed evaluation of the current evidence and treatment recommendations regarding third-generation ASMs. This guideline will help clinicians to better understand these medications and offer guidance for clinical practice.
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