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Scoping review: Sexual dysfunction in people with epilepsy.

Sumika Ouchida1, Armin Nikpour2, Greg Fairbrother3

  • 1Comprehensive Epilepsy Service, Royal Prince Alfred Hospital, Camperdown, Sydney, NSW 2050, Australia.

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|November 21, 2025
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Summary
This summary is machine-generated.

Sexual dysfunction is common in people with epilepsy (PWE), impacting their quality of life. More research and education are needed for effective diagnosis and treatment of these sexual problems.

Keywords:
AssessmentEpilepsyManagementPrevalenceSexual dysfunction

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Area of Science:

  • Neurology
  • Sexual Medicine
  • Public Health

Background:

  • Epilepsy is frequently associated with comorbidities that diminish the quality of life for people with epilepsy (PWE).
  • Sexual dysfunction (SD) is a significant comorbidity impacting PWE.

Purpose of the Study:

  • To review existing literature on sexual dysfunction in epilepsy.
  • To identify gaps in knowledge regarding the prevalence, types, and contributing factors of SD in PWE.
  • To examine current epilepsy care management strategies and treatment facilitators/barriers for SD.

Main Methods:

  • A systematic literature search was conducted across major databases (Embase, Medline, PsycINFO, PubMed).
  • Searched terms included "sexual dysfunction," "sexual problems," "sexual behaviour," and "erectile dysfunction" in relation to epilepsy.
  • Included English-language articles published between 2000 and 2023.

Main Results:

  • Sexual dysfunction is highly prevalent in people with epilepsy.
  • Multiple factors are associated with SD, which affects men and women differently.
  • Limited evidence supports available treatments for SD in PWE, and healthcare professional education on SD is insufficient.

Conclusions:

  • Sexual problems are a common issue for people with epilepsy.
  • Healthcare providers should consider drug-induced sexual problems, which significantly affect quality of life.
  • There is a need for established treatment guidelines, further research on treatments, and enhanced education for healthcare providers regarding SD in epilepsy.