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Association Between Peripheral Inflammation Biomarkers and Clinical Phenotypes in Patients With Medication Overuse
Changling Li1, Peiqi He1, Mengmeng Ma1
1Department of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Brain and Behavior
|November 22, 2025
Summary
Peripheral inflammation markers like Systemic Inflammation Index (SII) and Aggregate Index of Systemic Inflammation (AISI) are linked to medication overuse headache (MOH). Elevated levels of these biomarkers are associated with MOH and its clinical features.
Area of Science:
- Neurology
- Immunology
- Biomarker Research
Background:
- Peripheral inflammation's role in medication overuse headache (MOH) is not well understood.
- Investigating inflammatory biomarkers in MOH patients is crucial for understanding disease mechanisms.
Purpose of the Study:
- To investigate peripheral inflammation biomarkers in MOH patients.
- To examine the relationship between these biomarkers and clinical features of MOH.
Main Methods:
- Assessed inflammatory markers from blood cell counts in 128 MOH patients and 132 controls (60 episodic migraine, 72 healthy).
- Documented clinical features including headache frequency, intensity, and acute medication use.
Main Results:
- MOH patients showed higher Aggregate Index of Systemic Inflammation (AISI) than healthy controls.
- Systemic Inflammation Index (SII), SIRI, and AISI correlated with headache duration and acute medication use.
- AISI was more effective than SII and SIRI in diagnosing MOH; elevated SII and AISI were significantly associated with MOH.
Conclusions:
- Significant correlations exist between SII, SIRI, AISI, and MOH clinical phenotypes.
- Elevated SII and AISI levels are significantly linked to MOH.
- Peripheral inflammation biomarkers can enhance the understanding and diagnosis of MOH.
