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Related Experiment Video

Updated: Jan 10, 2026

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Studying Protein Function and the Role of Altered Protein Expression by Antibody Interference and Three-dimensional Reconstructions

Published on: April 21, 2016

Pre-programming the protein corona: From avoidance to endogenous targeting.

Nalla Usha Kumari¹, Sri Pada Datta Chigurupati¹, Naveen Rajana¹

¹Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana 500037, India.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|November 22, 2025

Summary

This summary is machine-generated.

The protein corona (PC) changes nanocarrier identity, impacting drug delivery. Manipulating the PC enables targeted delivery by leveraging endogenous ligands and AI for optimized nanomaterial design.

Keywords:

Endogenous targeting Nano-bio interactions Nano-biointerface Predefined PC Protein corona Targeted delivery

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Area of Science:

Nanomedicine
Biomaterials Science
Drug Delivery Systems

Background:

The protein corona (PC) forms on nanocarriers in vivo, altering their biological identity and interactions.
Understanding PC formation is crucial for predicting nanocarrier behavior and optimizing drug delivery.
Current research focuses on manipulating the PC for enhanced targeting and therapeutic efficacy.

Purpose of the Study:

To analyze the impact of the protein corona on nanocarrier biofate and in vivo behavior.
To review methods for modulating PC composition to achieve endogenous targeting.
To highlight the role of artificial intelligence in predicting PC formation and function.

Main Methods:

Review of existing literature on protein corona formation and its impact on nanocarriers.
Analysis of strategies for modulating PC composition for targeted drug delivery.
Discussion of the application of artificial intelligence in predicting corona-protein interactions.

Main Results:

The PC significantly alters nanocarrier properties, influencing interactions with biological systems.
Modulating PC composition can enable endogenous targeting via specific ligand adsorption.
Artificial intelligence shows promise in predicting PC formation and guiding nanocarrier design.

Conclusions:

The protein corona is a critical determinant of nanocarrier biofate and therapeutic outcomes.
Targeted modulation of the PC is a viable strategy for enhancing nanomedicine efficacy.
AI integration offers powerful tools for rational design of advanced nanocarriers for drug delivery.