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Review Article: CD151 and TGF-β in Colon Cancer Metastasis: Flavonoids and Their Targeted Delivery Systems
Rama Rao Malla1, Durga Bhavani Kundrapu2, B Priyamavada1
1Cancer Biology Laboratory, Department of Biochemistry and Bioinformatics, GITAM School of Science, GITAM (Deemed to Be University), Visakhapatnam-530045, Andhra Pradesh, India.
Abstract:
Colon cancer (CC) is the 3rd most prevalent cancer globally, following breast and lung cancer, with the second-highest mortality rate. Multiple risk factors contribute to CC, and metastasis is the primary cause of increased mortality among CC patients. Natural compounds have been investigated for their ability to concurrently influence various carcinogenic mechanisms by interfering with the expression or activity of their signaling targets. This review focuses on natural flavonoids such as quercetin, taxifolin, and rutin. We discuss how these bioactive compounds potentially mitigate metastasis and associated signaling pathways in colon cancer.
Insights
Natural flavonoids like quercetin, taxifolin, and rutin show promise in combating colon cancer (CC) metastasis. These compounds may interfere with signaling pathways, offering a potential strategy to reduce CC mortality.
Area of Science:
- Oncology
- Natural Product Chemistry
- Molecular Biology
Background:
- Colon cancer (CC) is a leading cause of cancer mortality worldwide.
- Metastasis is the primary driver of increased mortality in colon cancer patients.
- Natural compounds are being explored for their potential to target multiple cancer mechanisms.
Purpose of the Study:
- To review the potential of specific natural flavonoids in mitigating colon cancer metastasis.
- To explore the role of quercetin, taxifolin, and rutin in targeting colon cancer signaling pathways.
Main Methods:
- Literature review focusing on natural flavonoids and colon cancer.
- Analysis of signaling pathways implicated in colon cancer metastasis.
- Examination of the molecular mechanisms of quercetin, taxifolin, and rutin.
Main Results:
- Flavonoids like quercetin, taxifolin, and rutin exhibit potential anti-metastatic properties in colon cancer.
- These compounds may modulate key signaling pathways involved in cancer progression.
- Evidence suggests interference with the expression or activity of specific signaling targets.
Conclusions:
- Natural flavonoids represent a promising avenue for colon cancer therapeutic strategies.
- Quercetin, taxifolin, and rutin may offer a multi-targeted approach to inhibit colon cancer metastasis.
- Further research into these compounds could lead to novel treatments for colon cancer.
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