Facilitating Personalized Immunotherapy with Interventional Radiology and Tumor Organoids

Area of Science:

• Oncology
• Immunology
• Radiology

Background:

• Personalized immunotherapy aims for greater precision and reduced toxicity than traditional methods.
• Patient-derived tumor organoids (PDOs) offer a platform for developing personalized therapies.
• Interventional radiology (IR) is crucial for tumor sampling and targeted therapy delivery.

Purpose of the Study:

• To explore the role of interventional radiology (IR) in advancing personalized immunotherapy using patient-derived tumor organoids (PDOs).
• To highlight how IR can facilitate the development and clinical translation of organoid-based immunotherapies.

Main Methods:

• Utilizing patient-derived tumor organoids (PDOs) cultured from interventional radiology (IR) biopsy specimens.
• Co-culturing PDOs with autologous immune cells to identify and expand tumor-reactive T cells.
• Investigating the integration of IR-guided locoregional therapies with PDO platforms.

Main Results:

• PDO cultures amplify tumor biomass for neoantigen identification.
• Co-culture systems enable expansion of tumor-specific T cells, serving as biomarkers and therapeutic targets.
• IR can provide tumor samples for organoid culture and deliver therapies that prime systemic immune responses.

Conclusions:

• Interventional radiology (IR) is integral to the PDO-based personalized immunotherapy pipeline, from sampling to therapy delivery.
• Integrating IR interventions with the PDO platform can accelerate the clinical translation of personalized immunotherapies.
• This approach holds promise for enhancing precision and reducing toxicity in cancer treatment.