Next-Generation Approaches to Improve the Information Content of Interventional Radiology Biopsies

Image-guided core biopsies and fine needle aspirations (FNAs) are routinely performed by interventional radiology (IR) practitioners for a large variety of indications. However, such tissue sampling can be nondiagnostic in up to 20% of cases. The reasons are varied but include technical shortcomings that could ultimately be solved with new technologies. In this article, the authors highlight emerging multiplexed analytical technologies designed to enhance the information content and detection sensitivity from biopsies and FNAs. These technologies have much to offer not only in deciphering cellular heterogeneity and comprehensive immune cell profiling but also in advancing personalized clinical care and in developing improved therapeutics. As these multiplexed tissue sampling technologies continue to evolve, they are expected to become more relevant in IR practices of the future.