Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genomics02:02

Genomics

39.6K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.6K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

20.5K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
20.5K
Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.5K
Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

15.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
15.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Metal-phenolic networks: a promising strategy for cancer immunotherapy.

Journal of translational medicine·2026
Same author

Microbiota-dependent biotransformation of apiin drives butyrate-associated protection against colitis.

NPJ science of food·2026
Same author

Per- and polyfluoroalkyl substances in breast milk and child growth trajectories during the first two years: A prospective birth cohort study in Nanjing, China.

Journal of hazardous materials·2026
Same author

Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC).

Nature protocols·2026
Same author

Bilateral active chorioretinal lesions and fundus hemorrhage in a 23-month-old male with CYBB mutation: a case report.

Translational pediatrics·2026
Same author

AutoPCR: automated phenotype concept recognition by prompting.

Bioinformatics (Oxford, England)·2026

Related Experiment Video

Updated: Jan 10, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.2K

Developing a general AI model for integrating diverse genomic modalities and comprehensive genomic knowledge.

Zhenhao Zhang1, Xinyu Bao2, Linghua Jiang1

  • 1Gilbert S. Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, United States.

Nucleic Acids Research
|November 24, 2025
PubMed
Summary

A new artificial intelligence (AI) model integrates diverse genomic data, predicting gene transcription and regulatory element functions across species. This unified approach enhances understanding of genome regulation in humans and mice.

More Related Videos

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K
Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

763

Related Experiment Videos

Last Updated: Jan 10, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework
06:19

Constructing and Visualizing Models using Mime-based Machine-learning Framework

Published on: July 22, 2025

2.2K
Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches
09:47

Author Spotlight: Advancing Alzheimer's Research – Exploring Early Detection and Multi-Omics Approaches

Published on: December 15, 2023

1.7K
Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System
05:33

Introduction of an Integrated Pathology Image Management, Artificial Intelligence, and Reporting System

Published on: July 11, 2025

763

Area of Science:

  • Genomics
  • Artificial Intelligence
  • Computational Biology

Background:

  • Next-generation sequencing has generated vast amounts of genomic, epigenomic, and transcriptomic data.
  • Previous predictive models were often specialized for specific tasks, limiting their scope.
  • A unified model is needed to integrate comprehensive genomic knowledge.

Purpose of the Study:

  • To develop a general artificial intelligence (AI) model that integrates diverse genomic modalities into a unified framework.
  • To create a multi-task architecture capable of handling various genomic data types.
  • To enhance the understanding of genome regulation across different species.

Main Methods:

  • Developed a general AI model using a multi-task architecture.
  • Utilized ATAC-seq and DNA sequences as inputs.
  • Incorporated diverse genomic modalities (e.g., nascent RNA, chromatin organization) as outputs.
  • Extended the model from human to mouse data.

Main Results:

  • The AI model demonstrated strong generalizability across different cell types and tissues.
  • Accurately predicted gene-level transcription and enhancer-associated transcription.
  • Successfully identified the functions of non-coding genetic variants and regulatory elements.
  • Achieved accurate predictions of genomic modalities in mice, including chromatin contact maps, even with limited data.

Conclusions:

  • The developed general AI model offers a powerful tool for integrating and analyzing diverse genomic data.
  • This approach significantly advances the understanding of genome regulation in both human and mouse species.
  • The model's ability to generalize across tasks and species highlights its potential for broad applications in genomics research.